88805·pccn新蒲京(CHINA)官网·Popular Platform

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地址：北京市海淀区西小口路66号中关村东升科技园C-1楼三层

点击化学

点击反应是一类具有定量、快速、高效、立体选择性、很少甚至没有副产物生成、反应条件温和等特点的化学反应。点击化学在制药和生物技术行业的生物偶联应用中具有广泛的应用。

传统的叠氮-炔点击反应是指在铜(I)催化的条件下叠氮化物和端炔的1，3-偶极环加成反应。众所周知，铜(I)具有细胞毒性，可损伤红细胞，使传统的点击反应在生物医学应用中受到限制。88805·pccn新蒲京的聚乙二醇-环辛炔衍生物可以在无铜的条件下与叠氮化物反应，从而使后处理非常简单，消除了传统点击化学的细胞毒性问题。88805·pccn新蒲京PEG-环辛炔衍生物具有良好的水溶性和生物相容性，可广泛应用于多肽、蛋白质和药物传递送中，以延长半衰期，降低免疫原性和毒性，也可与药物分子通过PEG化结合，作为水凝胶的一部分，以达到对药物的缓释控制目的。

新型PEG环新炔衍生物的优点：

无铜条件下与叠氮化物进行点击反应;

与传统的点击化学相比，没有细胞毒性问题;

良好的水溶性和生物相容性;

延长半衰期，降低药物免疫原性和毒性;

多臂PEG环辛炔衍生物可用于形成水凝胶;

新蒲京具有提供大批量生产高品质高性价比PEG-DBCO产品的能力，包括非GMP和GMP级产品。下面是88805·pccn新蒲京生产的PEG DBCO产品的详细信息，具有不同分支、分子量和功能的PEG和单分散PEG DBCO衍生物可以通过客户特定合成服务进行合成。

Methoxy PEG DBCO Products

Item Number	Item Description
M-DBCO-2000	Methoxy PEG Dibenzocyclooctyne, MW 2000
M-DBCO-3500	Methoxy PEG Dibenzocyclooctyne, MW 3500
M-DBCO-5000	Methoxy PEG Dibenzocyclooctyne, MW 5000
M-DBCO-10K	Methoxy PEG Dibenzocyclooctyne, MW 10000
M-DBCO-20K	Methoxy PEG Dibenzocyclooctyne, MW 20000
M-DBCO-30K	Methoxy PEG Dibenzocyclooctyne, MW 30000
M-DBCO-40K	Methoxy PEG Dibenzocyclooctyne, MW 40000

Y-Shaped and U-Shaped PEG DBCO Products

Item Number	Item Description
Y-DBCO-40K	Y-shape (MPEG20K)2 Dibenzocyclooctyne, MW 40000
MPEG2-DBCO-40K	MPEG2 Dibenzocyclooctyne, MW 40000

Homobifunctional PEG DBCO Products

Item Number	Item Description
DBCO-PEG2000-DBCO	PEG (Dibenzocyclooctyne)2, MW 2000
DBCO-PEG5000-DBCO	PEG (Dibenzocyclooctyne)2, MW 5000
DBCO-PEG10K-DBCO	PEG (Dibenzocyclooctyne)2, MW 10000

Multi-arm PEG DBCO Products

Item Number	Item Description
4ARM-DBCO-10K	4arm PEG Dibenzocyclooctyne (pentaerythritol), MW 10000
4ARM-DBCO-20K	4arm PEG Dibenzocyclooctyne (pentaerythritol), MW 20000
8ARM(TP)-DBCO-10K	8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 10000
8ARM(TP)-DBCO-20K	8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 20000
8ARM(TP)-DBCO-40K	8arm PEG Dibenzocyclooctyne (tripentaerythritol), MW 40000

Heterobifunctional PEG DBCO Products

Item Number	Item Description
DBCO-PEG2000-SCM	Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 2000
DBCO-PEG3500-SCM	Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 3500
DBCO-PEG5000-SCM	Dibenzocyclooctyne PEG Succinimidyl Carboxymethyl Ester, MW 5000
DBCO-PEG2000-NH2TFA	Dibenzocyclooctyne PEG Amine, TFA Salt, MW 2000
DBCO-PEG3500-NH2TFA	Dibenzocyclooctyne PEG Amine, TFA Salt, MW 3500
DBCO-PEG5000-NH2TFA	Dibenzocyclooctyne PEG Amine, TFA Salt, MW 5000
DBCO-PEG2000-MAL	Dibenzocyclooctyne PEG Maleimide, MW 2000
DBCO-PEG3500-MAL	Dibenzocyclooctyne PEG Maleimide, MW 3500
DBCO-PEG5000-MAL	Dibenzocyclooctyne PEG Maleimide, MW 5000
DBCO-PEG2000-OH	Dibenzocyclooctyne PEG Hydroxyl, MW 2000
DBCO-PEG3500-OH	Dibenzocyclooctyne PEG Hydroxyl, MW 3500
DBCO-PEG5000-OH	Dibenzocyclooctyne PEG Hydroxyl, MW 5000
DBCO-PEG2000-OPSS	Dibenzocyclooctyne PEG OPSS, MW 2000
DBCO-PEG3500-OPSS	Dibenzocyclooctyne PEG OPSS, MW 3500
DBCO-PEG5000-OPSS	Dibenzocyclooctyne PEG OPSS, MW 5000